comparison of half-dose and full-dose triple therapy regimens for helicobacter pylori eradication in patients with end-stage renal disease

aim : the aim of this study was to compare the half-dose and full-dose triple therapy regimens for helicobacter pylori ( hp ) eradication in patients with end-stage renal disease. background : h. pylori is one the most important causes of dyspepsia in patients with end-stage renal disease (esrd). patients and methods : sixty-six patients with esrd were enrolled in the study with hp infection and peptic disease with a need of hp eradication. patients were randomly assigned to full-dose (a=35 patients) or half-dose group (b=31 patients). patients received clarithromycin 500 mg, amoxicillin 1000 mg and omeprazole 20 mg twice daily in group a and clarithromycin 250 mg and amoxicillin 500 mg twice daily and omeprazole 20 mg once daily in group b for two weeks. patients provided stool samples 4 weeks of completing study to assess the success of hp eradication by hp -specific stool antigen. finally, the rate of eradication and complications were compared between two groups. results : the successful hp eradication was achieved in 26 patients (74%) in group a and in 22 patients (74%) in group b. the difference between 2 groups was not statistically significant (p=0.973) (per protocol analysis). conclusion : half-dose triple-therapy with clarithromycin, amoxicillin and omeprazole is as effective as full-dose triple-therapy to eradicate the hp in patients with esrd. according to lower toxicity level, complications and cost in half-dose regimen in this subset of patients, this protocol is advised.